Preliminary affirmation from a analytic balloon suggests that analysis with glucagon-like peptide-1 (GLP-1) receptor agonists was associated with bargain anatomy accumulation basis and anatomy weight in adolescents with astringent obesity, according to a address appear Online First by JAMA Pediatrics.
GLP-1 receptor agonist therapy, accustomed for adults with blazon 2 diabetes mellitus, reduces anatomy weight by acceptable abhorrence and suppressing appetite, alike in patients after diabetes, according to the abstraction background.
Aaron S. Kelly, Ph.D., of the University of Minnesota Medical School, Minneapolis, and colleagues conducted a three-month, placebo-controlled balloon followed by a three-month open-label addendum during which medication was offered to all patients. A absolute of 22 patients (12 to 19 years of age) completed the trial, in which the medication exenatide was administered subcutaneously (injected).
“The after-effects of this analytic balloon extend the allegation of our antecedent pilot and achievability abstraction and action added evidence, aural the ambience of a randomized, placebo-controlled trial, that analysis with a GLP-1 receptor agonist decidedly reduces BMI and anatomy weight in adolescents with astringent obesity,” the authors note.
Exenatide acquired a greater abridgement in BMI compared with placebo (-2.7 percent). Advisers additionally empiric a added abridgement in BMI during the open-label appearance for those patients initially randomized to exenatide (cumulative BMI abridgement of
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